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There is no question that integrating AI into government operations is not just an opportunity — it is a necessity. However, with the increasing use of AI comes significant risks — ranging from security vulnerabilities and ethical concerns to potential misuse and unintended consequences. These risks underscore the importance of implementing robust AI governance frameworks to ensure AI systems and machine learning (ML) models behave responsibly. One such framework is the National Institute of Standards and Technology (NIST) Risk Management Framework (RMF), which provides voluntary guidelines for managing AI risks effectively. This blog delves into the challenges, current state of the market, and use cases for operationalizing the NIST AI RMF to ensure safe and trustworthy AI in government agencies.
Ensuring that AI systems align with an organization’s values and intended aims is crucial, particularly in government settings where public trust, national defense, and the well-being of citizens are at stake. To address this, NIST released its AI Risk Management Framework in 2023 — a voluntary guideline designed to promote best practices in AI risk mitigation.
The NIST AI RMF offers a comprehensive process for applying end-to-end risk management to activities such as building, operating, inspecting, and deploying AI systems. By applying the RMF to AI, government agencies can manage organizational risk more effectively, ensuring that information security and privacy programs are robust and adaptable.
At the core of the AI RMF are four key functions:
By embedding NIST AI RMF best practices into their operations, government agencies can get ahead of compliance, and build a solid foundation for managing AI risks today and in the future.
Despite the growing awareness of AI risks and the increasing regulatory scrutiny, many government agencies remain unprepared for the challenges posed by AI. Regulatory bodies in the United States, such as the Federal Reserve, Office of the Comptroller of the Currency (OCC), and the Securities and Exchange Commission (SEC), have already issued guidance on model risk management (MRM) for financial institutions. However, similar regulations are gradually being introduced across other sectors, and compliance is becoming increasingly complex.
Implementing the NIST AI RMF requires a comprehensive approach, and solutions like Domino Governance can play a critical role in this process. Embedded within the Domino Enterprise AI Platform, Domino Governance streamlines and automates the collection, review, and tracking of all materials required to enforce compliance with any policy — now and in the future. Domino’s solution simplifies AI governance at scale by embedding and automating the enforcement of current and future policies, such as the NIST AI RMF, within one system of record for mission-specific AI.
Key features include:
The urgency of adopting the NIST AI RMF cannot be overstated. As AI technologies continue to advance, and new regulations emerge, implementing the NIST AI RMF helps agencies establish a robust governance culture and foundation that enables them to address their missions through innovation. Domino plays a pivotal role in this process and transforms governance complexities into a swift and dependable process. Start your NIST AI RMF journey today, mitigate risks effectively, and empower trustworthy, responsible AI.
Take the first step now and check out this impact brief or the on-demand webinar.

Leila Nouri, Director of Product Marketing at Domino Data Lab, is an innovative and data-driven product marketing leader with 15+ years of experience building high-performing teams, go-to-market campaigns, and new revenue streams for startups and Fortune 500 companies.
Watch the 15 minute on-demand demo to get an overview of the Domino Enterprise AI Platform.
Watch the 15 minute on-demand demo to get an overview of the Domino Enterprise AI Platform.